3D structure of DNA Folding Generates Complex Patterns of Interactions
Researchers compared genome's 3D structure with known patterns of gene expression and splicing, after imaging the genome at high resolution. The study was published in Nature Genetics.
The study revealed that a protein's function cannot be inferred from the linear sequence of its constituent amino acids. The function is provided by the pattern of folding and same is true for DNA.
The study stated that their transcription is affected by the serpentine convolutions of DNA that expose certain exons and hide others.
This concluded that digital models of DNA's functions are incomplete. The gene expressions are controlled by the non-digital folding patterns of the genome.
The study was conducted by Tim Mercer and Professor John Mattick from the Garvan Institute of Medical Research in Sydney, Australia, and John Stamatoyannopoulos from the University of Washington in Seattle.
"We can infer that the genome is folded in such a way that the promoter region - the sequence that initiates transcription of a gene - is located alongside exons, and they are all presented to transcription machinery", Mercer said in a Garvan Institute press release.
The 3D structure of DNA folding can generate complex patterns of interactions, concluded the paper.
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