The Herpes Vaccine Appears to be Closer to Reality
Working towards development of vaccines for Herpes Simplex Virus, that causes severe brain ailment and infection in newborns, the scientists are now researching on how impervious cells behave all through the infection.
Cheryl Jones, lead investigator and Associate Professor, University of Sydney said "Herpes Simplex Virus (HSV) causes cold sore, genital herpes, serious brain disease and newborn-infections. The skin represents a major entry point; therefore, understanding how immune cells behave during the infection is of vital importance to researchers trying to find a cure for HSV".
For the promotion and transmission of HIV, the virus that causes AIDS, HSV infection of the skin and genital mucosa are important.
The research was a joint effort of the Centenary Institute and the Westmead Millennium Institute and the Sydney Medical School, Kids Research Institute at Children's Hospital at Westmead, Jones added.
They had used fluorescent viruses and mice, in which immune cells were marked with green fluorescent protein to learn, how the HSV virus affected immune cells after they entered the skin.
They hence found out that HSV was capable of infecting Langerhans cells, the immune cells in the top layer of the skin, but instead of making them egress the skin to the Lymph nodes to switch on a stronger immune response, they become sticky and die.
In this regard the other types of immune cells, deeper in the skin, seemed to be more significant.
For the first time it was shown that gamma delta T-cells in the skin could be infected with HSV, very soon after infection.
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