Vaccination for Rheumatoid Arthritis and Crohn's To Be Out Soon

VaccinationRecently, scientists of Weizmann Institute have claimed of having found a vaccine which could prove helpful in treating autoimmune diseases like as rheumatoid arthritis and Crohn's. The treatment thus claimed has proved successful on animal. A trial on human is yet to begin.

For the research, the scientists blocked the activities of notorious enzyme called MMP9, which is famous for getting out of control and trigger autoimmune diseases. The findings of the scientists have been published in the renowned pages of journal Nature Medicine.

It has been informed that generally, MMP9 are kept under check by inhibitor molecules called TIMPs. However, if MMP9 gets out of control then it may cause cancer metastasis and autoimmune diseases. Previously, many researchers, scientists and medical experts have tried to target MMP9 but they all had severe side effects.

Therefore, this time the scientists played smartly and found a way by which controlled MMP9 could be produced. The vaccine thus created though does target MMP9 but not directly. The scientists tested the vaccine over mice with a rodent version of Crohn's. It was found that inflammation of the disease reduced significantly with the introduction of the vaccine.

Professor Irit Sagi from the Weizmann Institute said, “We are excited not only by the potential of this method to treat Crohn's, but by the potential of using this approach to explore novel treatments for many other diseases”.

It is hoped that soon the treatment would become available for clinical use. If the vaccine proves affective in reducing the agony of autoimmune diseases then a large number of patients would be helped. It is estimated that about
400,000 people in England and Wales are affected with rheumatoid arthritis and 90,000 people with Crohn’s disease in the UK. Recently, scientists of Weizmann Institute have claimed of having found a vaccine which could prove helpful in treating autoimmune diseases like as rheumatoid arthritis and Crohn's. The treatment thus claimed has proved successful on animal. A trial on human is yet to begin.

For the research, the scientists blocked the activities of notorious enzyme called MMP9, which is famous for getting out of control and trigger autoimmune diseases. The findings of the scientists have been published in the renowned pages of journal Nature Medicine.

It has been informed that generally, MMP9 are kept under check by inhibitor molecules called TIMPs. However, if MMP9 gets out of control then it may cause cancer metastasis and autoimmune diseases. Previously, many researchers, scientists and medical experts have tried to target MMP9 but they all had severe side effects.

Therefore, this time the scientists played smartly and found a way by which controlled MMP9 could be produced. The vaccine thus created though does target MMP9 but not directly. The scientists tested the vaccine over mice with a rodent version of Crohn's. It was found that inflammation of the disease reduced significantly with the introduction of the vaccine.

Professor Irit Sagi from the Weizmann Institute said, “We are excited not only by the potential of this method to treat Crohn's, but by the potential of using this approach to explore novel treatments for many other diseases”.

It is hoped that soon the treatment would become available for clinical use. If the vaccine proves affective in reducing the agony of autoimmune diseases then a large number of patients would be helped. It is estimated that about
400,000 people in England and Wales are affected with rheumatoid arthritis and 90,000 people with Crohn’s disease in the UK.

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