Growth hormone and breast cancer
The Independent reported “A hormone that helps children grow may cause breast cancer, and women with high levels are at higher risk”. The study was carried out by researchers from the Endogenous Hormones and Breast Cancer Collaborative Group in the Cancer Epidemiology at the University of Oxford. Contributors from institutes in Europe, The US and Australia also took part. In total 17 studies matched the inclusion criteria, providing data on 4,790 women who developed breast cancer and 9,428 women who did not develop the disease and who formed the control group. The result was IGF1 concentrations were higher in certain groups, including taller women, moderately overweight and in moderate consumers of alcohol.
Oncologist Dr. Samuel Aparicio , who is also the lead author of the report findings in the Journal Nature said here on Thursday “The point is, unless we start thinking about targeting the cancer with multiple drugs at the beginning, we're going to go on seeing treatment failures”. Underscoring the need for multi proved treatment, there were several different mutations creating different types of cancer cells in the woman’s tumor right from the beginning. He says “Within a few years, we might be able to get the cost down to a few thousand dollars per patient” as more personalized treatment that sequences each patients cancer could soon be within reach given the dropping costs and “phenomenal” increase in the power and speed of gene sequencing.
The researchers point out that individual study designs and methods often vary and in this case, IGF1 and IGFB3 and other risk factors were measured using various methods, which could make the results less reliable and also the hormone concentrations varied substantially between studies, The reason for this is unclear although hormone levels were measured only on one occasion, and may not necessarily represent hormone levels over a woman’s lifetime.
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