Treatment for HIV and Cancer: A Trial Gene Therapy

Treatment for HIV and Cancer: A Trial Gene TherapyFor the very first time, it has been discovered that anti-HIV genes can treat the people with AIDS-related lymphoma. It was in US, that a small medical experiment of RNA-based gene therapy was conducted, wherein; patients were medicated with genetically engineered editions of their own stem cells.

The researchers are now in a hope that this gene therapy may perhaps ultimately yield a treatment for both the cancer and the HIV infection. This study was conducted at the City of Hope Cancer Center in Duarte, California.

Lymphoma is a cancer of the immune system, and some AIDS patients develop this disease. They were put under the treatment of autologous HCT (hematopoietic cell transplantation), which is a stem cell cure that substitutes the diseased bone marrow with healthy and working cells.

With this treatment, the core HIV infection is not addressed, but the lymphoma is put to diminution. In this study, Senior Author Dr. John Zaia, Aaron D. and Edith Miller Chair in Gene Therapy and Chair of Virology at City of Hope, has treated four patients, who were passing with the regular HCT.

Zaia and his colleagues, said, "We still see evidence that the patients are producing the therapeutic genes, including the siRNA, as long as two years after transplant. These results support the development of an RNA-based cell therapy platform for HIV".